プレスリリース（2021年～2023年）
＜2024年＞
2024.06.25
「牛伝染性リンパ腫ウイルス簡易迅速定量法 BLV-CoCoMo Dual qPCR法とその乾燥試薬の開発に成功」
＜2023年＞
2023.08.28
「犬・猫との共生を阻む社会課題の大きな原因、 動物アレルギーを克服する新しい一歩 ――光触媒で溶液と乾燥状態のイヌアレルゲンとネコアレルゲンの分解に成功――」
＜2022年＞
2022.08.09
「光触媒で致死率の高い肺炎の原因であるレジオネラ菌の殺菌と敗血症を惹起するそのエンドトキシンの分解に成功」
＜2021年＞
2021.07.05
(理研)「紫外線照射による新型コロナウイルス不活化のメカニズム-ウイルスRNAの損傷が原因だった-」
(東大)「紫外線照射による新型コロナウイルス不活化のメカニズム-ウイルスRNAの損傷が原因だった-」
2021.05.21
「光触媒で空気中に浮遊する”新型コロナウイルス”の感染性を検出限界以下まで消失させることに成功～「Withコロナ」の社会の実現と新たな社会的脅威「変異ウイルス」への対抗策を提示～」
研究業績一覧（2009年～2024年）
＜2024年＞
１）原著論文
Watanuki S., Shoji K., Izawa M., Okami M., Ye Y., Bao A., Liu Y., Saitou E., Sugiyama K., Endo M., Matsumoto Y., Aida Y.*, “Development of Dry and Liquid Duplex Reagent Mix-Based Polymerase Chain Reaction Assays as Novel Tools for the Rapid and Easy Quantification of Bovine Leukemia Virus (BLV) Proviral Loads”, Viruses,;2024 June 25;16(7), 1016; https://doi.org/10.3390/v16071016
Hamada R., Giovambattista G, Metwally S., Borjigin L., Yamanaka M., Matsuura R., Ali A., Mahmoud H.,
Mohamed A, Moe KK., Takeshima S-n., Wada S., Aida Y.*, “First characterization of major histocompatibility complex class II DRB3 diversity in cattle breeds raised in Egypt”, Gene,;2024 Apr 20:918:148491. doi: 10.1016/j.gene.2024.148491. Online ahead of print.
２）総説
綿貫 園子、松本 安喜、間 陽子牛伝染性リンパ腫ウイルスの簡易迅速診断法の開発：アグリバイオ vol.8、No.7、47-49、2024
松浦 遼介、間 陽子：光技術による動物アレルゲンの分解：光アライアンス 第35巻、第2号、48－51項、2024
３）特許出願
４）受賞
＜2023年＞
１）原著論文
Bai L., Soya M., Ichikawa M., Matsuura R., Arimura Y., Wada S., Aida Y.*, “Antigenicity of subregions of recombinant bovine leukemia virus (BLV) glycoprotein gp51 for antibody detection” J Virol Methods,; Jan;311:114644, doi: 10.1016/j.jviromet.2022
Kohara J.*, Bai L., Takeshima S-n., Matsumoto Y., Hirai T., Aida Y.*, “Correlation between the Biodistribution of Bovine Leukemia Virus in the Organs and the Proviral Load in the Peripheral Blood during Early Stages of Experimentally Infected Cattle” Pathogens 2023,; 12, 130., DOI: 10.3390/pathogens12010130
Nakatsuchi A, Matsumoto Y, Aida Y.*, “Influence of BoLA-DRB3 Polymorphism and Bovine Leukemia Virus (BLV) Infection on Dairy Cattle Productivity” Vet Sci.; Mar 27;10(4):250., DOI:10.3390/vetsci10040250
Borjigin, L., Watanuki, S., Hamada, R., Bai, L., Hirose, T., Sato, H., Yoneyama, S., Yasui, A., Yasuda, S., Yamanaka, R., Mimura, M., Baba, M., Inokuma, M., Fujita, K., Shinozaki, Y., Tanaka, N., Takeshima, S., Aida Y.*, “Effectiveness of integrated bovine leukemia virus eradication strategies utilizing cattle carrying resistant and susceptible major histocompatibility complex class II DRB3 alleles” J. Dairy Science,; S0022-0302(23)00566-0., https://doi.org/10.3168/jds.2023-23524
Matsuura R., Kawamura A., Ota R., Fukushima T., Fujimoto K., Kozaki M., Yamashiro M., Somei J., Matsumoto Y., Aida Y.*, “TiO2-Photocatalyst-Induced Degradation of Dog and Cat Allergens under Wet and Dry Conditions Causes a Loss in Their Allergenicity” Toxins,; Aug 21;11(8):718., doi: 10.3390/toxics11080718.
Hamada R., Metwally S., Matsuura R., Borjigin L., Lo Cw., Ali AO., Mohamed AEA., Wada S., Aida Y., “ BoLA-DRB3 Polymorphism Associated with Bovine Leukemia Virus Infection and Proviral Load in Holstein Cattle in Egypt”. Pathogens. 2023 Dec 14;12(12):1451. doi: 10.3390/pathogens12121451.
２）総説
松浦遼介、間陽子：光技術によるウイルスの不活化：The Japanese Sorcery for Animal Vaccine and Biomedical Research. ニュースレター２７号、14－21項、2023
間陽子：小沼操先生を偲んで: The Japanese Sorcery for Animal Vaccine and Biomedical Research. ニュースレター28号、6－7項、2023
間陽子: EBL の疾患感受性とそれを考慮したワクチン開発:The Japanese Sorcery for Animal Vaccine and Biomedical Research. ニュースレター28号、8－11項、2023
３）特許出願
発明の名称：非複製型牛伝染性リンパ腫ウイルス（BLV）及びその産生株
発明者：間陽子、メトワリ サミー ガマル アサイド ムハメド、松浦遼介
出願番号：特願2022-069710号
出願日：2023年４月２０日
出願人：東京大学
国際出願
Title： Non-replicating bovine infectious lymphoma virus（BLV）and cells for producing same.
発明の名称：非複製型牛伝染性リンパ腫ウイルス（ＢＬＶ）およびその産生細胞
発明者 間陽子、メトワリ サミー ガマル アサイド ムハメド、松浦遼介
出願番号：PCT/JP2023/15633
出願日：2023年４月１９日(19.04.2023)
出願人：東京大学
発明の名称：非複製型牛伝染性リンパ腫ウイルス（ＢＬＶ）ワクチン
発明者：間陽子、メトワリ サミー ガマル アサイド ムハメド、松浦遼介
出願番号： 2023-183308
出願日：2023年10月25日
出願人：東京大学
４）受賞
氏名：中土 亜由美
年月：2023年3月
賞名：東京大学大学院農学生命科学研究科 研究科長賞
氏名：綿貫 園子
年月：2023年7月
学術集会：39th International Society for Animal Genetics Conference(ISAG)
賞名：Travel Bursary Award
演題名：「Development of a rapid SNP genotyping assay for novel SNPs associated with BLV-induced lymphoma」
氏名：松浦 遼介
年月：2023年9月
学術集会：第31回日本組織適合性学会大会
賞名：学術奨励賞優秀賞
演題名：「新規Reverse vaccinology手法による牛伝染性リンパ腫ウイルス(BLV)のウイルス様粒子ワクチンの開発」
氏名：永田 文宏
年月：2023年9月
学術集会：第31回日本組織適合性学会大会
賞名：大会長賞
演題名：「BoLA領域のターゲットリシークエンス法を用いた相関解析による乳房炎発症関連遺伝子の解析」
氏名：叶 穎宝
年月：2023年11月
学術集会：日本動物遺伝育種学会第24回大会
賞名：優秀賞
演題名：「伝染性リンパ腫ウイルスのプロウイルス量に関わるSNPの迅速タイピング法の開発」
＜2022年＞
１）原著論文
Nakatsuchi A., Watanuki S., Borjigin L., Sato H., Bai L., Matsuura R., Kuroda M., Murakami H., Sato R., Asaji S., Ando A., Matsumoto Y., Takeshima S-n. and Aida Y.*, “BoLA-DRB3 Polymorphism Controls Proviral Load and Infectivity of Bovine Leukemia Virus (BLV) in Milk” Pathogens; 11, 210, DOI: 10.3390/pathogens11020210
Nguyen TDLVS., Lo Cw., Dao DT., Bui NV., Ogawa H., Imai K., Sugiura K., Aida Y.*, Haga T*, “Association between BoLA-DRB3 polymorphism and bovine leukemia virus proviral load in Vietnamese Holstein Friesian cattle” HLA,; 99(2):105-112, DOI: 10.1111/tan.14503
Sato H., Murakami T., Matsuura R., Abe M., Matsuoka S., Yashiroda Y., Yoshida M., Akari H., Nagasawa Y., Takei M., Aida Y.*, “A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening” Viruses; Jun 16;14(6):1321, doi: 10.3390/v14061321
Sato H, Fukui JN, Hirano H, Osada H, Arimura Y, Masuda M, Aida Y.*, “Application of the Luminescence Syncytium Induction Assay to Identify Chemical Compounds That Inhibit Bovine Leukemia Virus Replication” Viruses; Dec 20;15(1):4, doi: 10.3390/v15010004.
米山州二、齊藤かおり、小笠原悠、陸拾七、間陽子, “栃木県の牛伝染性リンパ腫ウイルス高度感染酪農場における清浄化事例” 日本獣医師会雑誌; 75:114-121, https://doi.org/10.12935/jvma.75.e114
Yamanaka PM., Saito S., Hara Y., Matsuura R., Takeshima S-n., Hosomichi K., Matsumoto Y., Furuta RA., Takei M., Aida Y.*, “No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan” Retrovirology,; May 18;19(1):7;, doi: 10.1186/s12977-022-00592-6.
Yamanaka PM., Saito S., Hosomichi K., Aida Y.*, “Comprehensive Comparison of Novel Bovine Leukemia Virus (BLV) Integration Sites between B-Cell Lymphoma Lines BLSC-KU1 and BLSC-KU17 Using the Viral DNA Capture High-Throughput Sequencing Method” Viruses,; May 7;14(5):995;, doi: 10.3390/v14050995.
Matsuura R., Kawamura A., Matsumoto Y., Fukushima T., Fujimoto K., Ochiai H., Somei J., Aida Y.*, “Rutile-TiO2/PtO2 Glass Coatings Disinfects Aquatic Legionella pneumophila via Morphology Change and Endotoxin Degradation under LED Irradiation” Catalysts; 12, 856, doi.org/10.3390/catal12080856
Matsuura R., Maeda K., Hagiwara K., Mori Y., Kitamura T., Matsumoto Y., Aida Y.*, “WO3 Photocatalyst Containing Copper Inactivates SARS-CoV-2 Pango Lineage A and Omicron BA.2 Variant in Visible Light and in Darkness” Pathogens; 11, 922., doi.org/10.3390/pathogens11080922
Matsuura R., Lo Cw., Ogawa T., Nakagawa M., Takei M., Matsumoto Y., Wada S., Aida Y.*, “Comparison of the inactivation capacity of various UV wavelengths on SARS-CoV-2” Biochem Biophys Rep; Dec;32:101379., doi: 10.1016/j.bbrep.2022.101379
Matsuura R., Kawamura A., Matsumoto Y., Iida Y., Kanayama M., Kurokawa M., Aida Y.*, “Epigallocatechin Gallate Stabilized by Cyclodextrin Inactivates Influenza Virus and Human Coronavirus 229E” Microorganisms; 6;10(9):1796., doi: 10.3390/microorganisms10091796.
Nakatsuchi A., Bao A., Watanuki S., Matsuura R., Borjigin L., Bai L., Kuroda M., Matsumoto Y., Kohara J., Aida Y.*, “Anti-BLV antibodies in whey correlate with bovine leukemia virus disease progression and BoLA-DRB3 polymorphism” Front Vet Sci.; Nov 25;9:1038101, doi: 10.3389/fvets.2022.1038101.
Saito S., Hosomichi K., Yamanaka PM., Mizutani T., Takeshima S-n., Aida Y.*, “Visualization of clonal expansion after massive depletion of cells carrying the bovine leukemia virus (BLV) integration sites during the course of disease progression in a BLV naturally-infected cow: a case report” Retrovirology; Nov 3;19(1):24, doi: 10.1186/s12977-022-00609-0.
２）総説
Chieh-Wen Lo, Yoko Aida：Association of BoLA-DRB3 with bovine leukemia virus、日本組織適合性学会誌 29 巻 (2022) 3 号
４）受賞
氏名：中土 亜由美
年月：2022年9月
学術集会：第30回日本組織適合性学会大会
賞名：学術奨励賞優秀賞
演題名：「BoLA-DRB3遺伝子が牛伝染性リンパ腫ウイルス感染牛の乳汁に与える影響」
氏名：松浦 遼介
年月：2022年11月
学術集会：日本動物遺伝育種学会第23回大会
賞名：特別賞最優秀賞
演題名：「牛伝染性リンパ腫ウイルス（BLV）感受性の主要組織適合遺伝子複合体を有する個体に最適化したBLVウイルス様粒子ワクチンの開発」
＜2021年＞
１）原著論文
松浦遼介 , Lo Chieh-Wen, 中川 優 , 武井正美 , 間 陽子, “新型コロナウイルス SARS- CoV-2 の診断キットの前処理試薬のウイルス不活化効果の評価” 日本家畜衛生学雑誌; 46: 195 ? 203
Lo CW., Takeshima S-n., Okada K., Saitou E., Fujita T., Matsumoto Y., Wada S., Inoko H., Aida Y.*, “Association of Bovine Leukemia Virus-Induced Lymphoma with BoLA-DRB3 Polymorphisms at DNA, Amino Acid, and Binding Pocket Property Levels” Pathogens,; 10(4):437, doi: 10.3390/pathogens10040437.
Lo CW., Takeshima S-n., Matsumoto Y., Wada S., Aida Y.*, “Bovine major histocompatibility complex (BoLA) heterozygote advantage against the outcome of bovine leukemia virus infection” HLA,; 1?8, DOI: 10.1111/tan.14285
Lo C-w., Matsuura R., Iimura K., Wada S., Shinjo A., Benno Y., Nakagawa M., Takei M., Aida Y.*, “UVC disinfects SARS-CoV-2 by induction of viral genome damage without apparent effects on viral morphology and proteins” Scientific Report,; 11(1):13804, doi: 10.1038/s41598-021-93231-7
Matsuura R, Lo Cw, Wada S, Somei J, Ochiai H, Murakam T, Saito N, Ogawa T, Shinjo A, Benno Y, Nakagawa M, Takei M, Aida Y.*, “SARS-CoV-2 Disinfection of Air and Surface Contamination by TiO2 Photocatalyst-Mediated Damage to Viral Morphology, RNA, and Protein” Viruses,; 13(5):942, doi: 10.3390/v13050942
Borjigin L, Yoneyama S, Saito S, Polat M, Inokuma M, Shinozaki Y, Tanaka N, Yamanaka R, Yasui A, Mimura M, Murakami H, Takeshima SN, Aida Y.*, “A novel real time PCR assay for bovine leukemia virus detection using mixed probes and degenerate primers targeting novel BLV strains” J Virol Methods; 297:114264, DOI: 10.1016/j.jviromet.2021.114264
Murakami T., Matsuura R., Nopporn Chutiwitoonchai, and Aida Y.*, “Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages” Viruses,; 13, 2308, doi: 10.3390/v13112308
Borjigin L., Lo Cw., Bai L., Hamada R., Sato H., Yoneyama S, Yasui A., Yasuda S., Yamanaka R., Mimura M., Inokuma M., Shinozaki Y., Tanaka N., Takeshima S-n. and Aida Y.*, “Risk Assessment of Bovine Major Histocompatibility Complex Class II DRB3 Alleles for Perinatal Transmission of Bovine Leukemia Virus” Pathogens,; 10, 502, DOI: 10.3390/pathogens10050502
Bai L., Borjigin L., Sato H., Takeshima S-n., Asaji S., Ishizaki H., Kawashima K., Obuchi Y., Sunaga S., Ando A., Inoko H., Wada S. and Aida Y.*, “Kinetic Study of BLV Infectivity in BLV Susceptible and Resistant Cattle in Japan from 2017 to 2019” Pathogens; 10, 1281, DOI: 10.3390/pathogens10101281
２）総説
白ランラン、和田智、間陽子：牛伝染性リンパ腫の個体差を克服可能なワクチン候補となる牛伝染性リンパ腫ウイルスのエピトープの探索、日本動物遺伝育種学会誌、第49巻、第2号、49-58 頁, 2021
４）受賞
氏名：Lo Chieh-Wen
年月：2021年9月
学術集会：第29回日本組織適合性学会大会
賞名：学術奨励賞最優秀賞
演題名：「Association of Bovine Leukemia Virus-Induced Lymphoma with BoLA-DRB3 Polymorphisms at DNA, Amino Acid, and Binding Pocket Property Levels」
氏名：中土 亜由美
年月：2021年11月
学術集会：日本動物遺伝育種学会第22回大会
賞名：特別賞最優秀賞
演題名：「BoLA-DRB3遺伝子が牛伝染性リンパ腫ウイルス感染牛の乳汁に与える影響」
氏名：白 兰兰
年月：2021.9.7-9
賞名：日本獣医学会獣医学奨励賞
「ワクチン開発のための牛伝染性リンパ腫ウイルスのエピトープマッピングおよび感染レセプターの同定」
氏名：Chieh-Wen Lo
年月：2021.9.3-5
賞名：日本組織適合性学会学術奨励賞優秀賞
「Association of Bovine Leukemia Virus-Induced Lymphoma with BoLA-DRB3 Polymorphisms at DNA, Amino Acid, and Binding Pocket Property Levels」
＜2020年＞
１）原著論文
Moe KK., Polat M., Borjigin L, Hein ST, Moe HH., Aida Y. , “New evidence of bovine leukemia virus circulating in Myanmar cattle through epidemiological and molecular characterization” PloS ONE; 21;15(2):e0229126, doi: 10.1371/journal.pone.0229126. eCollection
Sato H., Bai L., Borjigin L., Aida Y.*, “Overexpression of bovine leukemia virus receptor SLC7A1/CAT1 enhances cellular susceptibility to BLV infection on luminescence syncytium induction assay (LuSIA)” Virology Journal,; Apr 22;17(1):57, doi: 10.1186/s12985-020-01324-y.
Chang H., Siarot L., Matsuura R., Lo CW., Sato H., Otsuki H., Aida Y.*, “Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins” Viruses,; Jan 15;12(1). pii: E98., doi: 10.3390/v12010098
Murakami H., Suzuki T., Tsuchiya K., Gatanaga H., Taura M., Kudo E., Okada S., Takei M., Kuroda K., Yamamoto T., Hagiwara K., Domae N., Aida Y.*, “Protein Arginine N-methyltransferases 5 and 7 Promote HIV-1 Production” Viruses,; Mar 23;12(3). pii: E355., doi: 10.3390/v12030355.
Lo CW., Borjigin L., Saito S., Saitou E., Koya F., Okazaki K., Mizutani T., Wada S., Takeshima S-n., Aida Y.*, “BoLA-DRB3 Polymorphism is Associated with Differential Susceptibility to Bovine Leukemia Virus-Induced Lymphoma and Proviral Load” Viruses,; Mar 22;12(3). pii: E352., doi: 10.3390/v12030352.
Giovambattista G, Moe KK, Polat M, Borjigin L, Hein ST, Moe HH, Takeshima S-n, Aida Y.*, “Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar” BMC Genomics,; 21(1):95, doi: 10.1186/s12863-020-00905-8.
Giovambattista G.*, Takeshima S-n., Moe KK., Juan A., Rico P., Palat M., Vega AL., Cabrera ONA., Aida Y.*, “BoLA-DRB3 genetic diversity in Highland Creole cattle from Bolivia” HLA,; 96(6):688-696, doi: 10.1111/tan.14120. Epub 2020 Nov 5.
Assi W., Hirose T, Wada S., Matsuura R., Takeshima S-n., and Aida Y.*, “PRMT5 Is Required for Bovine Leukemia Virus Infection In Vivo and Regulates BLV Gene Expression, Syncytium Formation, and Glycosylation In Vitro” Viruses,; 12, DOI: 10.3390/v12060650
Hamada R, Metwally S, Polat M, Borjigin L, Ali AO, Abdel-Hady AAA, Mohamed AEA, Wada S, Aida Y., “Detection and Molecular Characterization of Bovine Leukemia Virus in Egyptian Dairy Cattle” Front. Vet. Sci.; 7:608,, DOI: 10.3389/fvets.2020.00608
Metwally S, Hamada R, Ali AO, Mahmoud HYAH, Baker NM, Mohamed AEA, Wada S, Matsumoto Y, Aida Y.*, “Detection and molecular characterization of bovine leukemia virus in beef cattle presented for slaughter in Egypt” J Vet Med Sci.,; 82(11):1676-1684, doi: 10.1292/jvms.20-0477. Epub 2020 Oct 20.
Bai L., Hirose T., Assi W, Wada S., Takeshima S-n., Aida Y.*, “Bovine Leukemia Virus Infection Affects Host Gene Expression Associated with DNA Mismatch Repair” Pathogens,; 9(11):909, doi: 10.3390/pathogens9110909.
４）受賞
氏名：Chieh-Wen Lo
年月：2020年11月
学術集会：日本動物遺伝育種学会第21回大会
賞名：優秀賞
演題名：「Bioinformatics analysis and experimental infection confirming bovine MHC DRB3 polymorphisms determine Bovine leukaemia virus proviral load in cattle」
＜2019年＞
１）原著論文
Bai L., Yokoyama K., Watanuki S., Takeshima S-n., and Aida Y.*, “Development of a new recombinant p24 ELISA system for diagnosis of bovine leukemia virus in serum and milk” Arch. Virol.; 164(1):201-211, DOI: 10.1007/s00705-018-4058-5
Tohma D., Tajima S., Kato F., Sato H., Kakisaka M., Hishiki T., Kataoka M., Takeyama H., Lim CK., Aida Y., and Saijo M. , “An estrogen antagonist, cyclofenil, has anti-dengue-virus activity” Arch. Virol.; 164(1):225-234, DOI: 10.1007/s00705-018-4079-0
Benitez-Rojas, O. J., Roberts J., Norby B., Bartlett P., Takeshima S-n., Watanuki S., Aida Y., and Grooms D. , “Breeding bulls as a potential source of bovine leukemia virus transmission in beef herds” Journal of the American Veterinary Medical Association; 254(11):1335-1340, doi: 10.2460/javma.254.11.1335.
Sato H., Watanuki S., Bai L., Borjigin L., Ishizaki H., Matsumoto Y., Hachiya Y., Sentsui H., Aida Y.*, “A sensitive luminescence syncytium induction assay (LuSIA) based on a reporter plasmid containing a mutation in the glucocorticoid response element in the long terminal repeat U3 region of bovine leukemia virus” Virology Journal.; 6:66, doi.org/10.1186/s12985-019-1172-2
Takeshima S-n., Ono A, Aida Y.*, “Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan” Retrovirology; 16:14, doi: 10.1186/s12977-019-0476-z.
Nishikaku K., Ishikura R., Ohonuki N., Polat M., Aida Y., Murakami S. and Kobayashi T. , “Broadly applicable PCR restriction fragment length polymorphism method for genotyping bovine leukemia virus” J Vet Med Sci.; 24;81(8):1157- 1161,, doi: 10.1292/jvms.18-0603
Watanuki S, Takeshima S-n, Borjigin L, Sato H, Bai L, Murakami H, Sato R, Ishizaki H, Matsumoto Y, Aida Y.*, “Visualizing bovine leukemia virus (BLV)-infected cells and measuring BLV proviral loads in the milk of BLV seropositive dams” Vet Res.; 29;50(1):102, doi: 10.1186/s13567-019-0724-1
Bai L., Takeshima S-n., Sato M, Davis W. C., Wada S., Kohara J., Aida Y.*, “Mapping of CD4+ T-cell epitopes in bovine leukemia virus from five cattle with differential susceptibilities to bovine leukemia virus disease progression” Virology Journal,; 16;16(1):157., doi: 10.1186/s12985-019-1259-9.
Bai L., Sato H., Kubo Y., Wada S., Aida Y.*, “CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection” FASEB J.; Dec;33(12):14516-14527, doi: 10.1096/fj.201901528R. Epub 2019 Oct 24.
Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima S-n., Takei M, Aida Y.*, “Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines” Arch Virol.; 165(1), 207-214, doi: 10.1007/s00705-019-04474-9.
若槻拓司 , 杉本定、高橋亜沙子、橋田明彦、水上智秋、広瀬友理、門田耕一、間 陽子, “若齢牛における地方病性牛白血病と診断した一例” 日本獣医師会雑誌（J. Japan Vet. Medical Sci.）; 72 (10): 608-613, doi: https://doi.org/10.12935/jvma.72.608
Matsuura R, Inabe K, Otsuki H, Kurokawa K, Dohmae N, Aida Y.*, “Three YXXL Sequences of a Bovine Leukemia Virus Transmembrane Protein are Independently Required for Fusion Activity by Controlling Expression on the Cell Membrane” Viruses,; Dec 10;11(12), doi: 10.3390/v11121140.
２）総説
竹嶋伸之輔、間陽子：ウシ主要組織適合遺伝子クラスIIの多様性の解析とウシ慢性感染症との関連性、宮城県獣医師会会報、第72巻、第2号、115-120 頁, 2019
４）受賞
氏名：Rania Hamada
年月：2019年11月
学術集会：日本動物遺伝育種学会第20回大会
賞名：優秀賞
演題名：「Isolation and molecular characterization of Bovine Leukemia Virus in Egypt」
＜2018年＞
１）原著論文
Sato H, Watanuki S, Murakami H, Sato R, Ishizaki H, Aida Y.*, “Development of a luminescence syncytium induction assay (LuSIA) for easily detecting and quantitatively measuring bovine leukemia virus infection” Arch. Virol.; 163(6):1519-1530, DOI: 10.1007/s00705-018-3744-7
Takeshima S-n., Corbi-Botto C., Giovambattista G., Aida Y.*, “Genetic diversity of BoLA-DRB3 in South American Zebu cattle populations” BMC Genet.; 19(1):33., doi.org/10.1186/s12863-018-0618-7
Murakami H, Uchiyama J, Suzuki C, Nikaido S, Shibuya K, Sato R, Maeda Y, Tomioka M, Takeshima SN, Kato H, Sakaguchi M, Sentsui H, Aida Y, Tsukamoto K. , “Variations in the viral genome and biological properties of bovine leukemia virus wild-type strains” Virus Research; 253:103-111, doi.org/10.1016/j.virusres.2018.06.005
Siarot L, Chutiwitoonchai N, Sato H, Chang H, Sato H, Fujino M, Murakami T, Aono T, Kodama E, Kuroda K, Takei M, Aida Y.*, “Identification of human immunodeficiency virus type-1 Gag-TSG101 interaction inhibitors by high-throughput screening” BBRC.; 503(4):2970-2976, doi.org/10.1016/j.bbrc.2018.08.079
２）著書
間陽子、竹嶋伸之輔：第6章 獲得免疫における主要組織適合遺伝子複合体（MHC）と抗原提示細胞、獣医免疫学第2版、pp86-99頁、株式会社緑書房（監修 池田輝雄ほか）、2018
４）受賞
氏名：綿貫 園子
年月：2018年3月
賞名：東京大学大学院農学生命科学研究科 研究科長賞
氏名：竹嶋 伸之輔 (理化学研究所 牛白血病ワクチン開発チーム)
年月：2018.9.11-13
賞名：日本獣医学会日本獣医学会賞
「ウシ主要組織適合遺伝子クラスⅡの解析と疾患感受性との相関性 Study of bovine major histocompatibility complex class II and disease susceptibility」
＜2017年＞
１）原著論文
Polat M, Moe HH, Shimogiri T., Moe KK., Takeshima S-n., Aida Y.*, “The molecular epidemiological study of bovine leukemia virus infection in Myanmar cattle” Arch. Virol.; 162(2) 425?437, DOI: 10.1007/s00705-016-3118-y
Takeshima S-n, Sasaki S., Meripet P., Sugimoto Y., Aida Y.*, “Single nucleotide polymorphisms in the bovine MHC region of Japanese Black cattle are associated with bovine leukemia virus proviral load” Retrovirology.; 14(1):24, DOI https://doi.org/10.1186/s12977-017-0348-3
Nopporn Chutiwitoonchai, Mano M., Kakisaka M., Sato H, Kondoh Y., Osada H., Kotani O., Yokoyama M., Sato H, and Aida Y.*, “Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development” Virology; 507:32-39, DOI: 10.1016/j.virol.2017.04.001
Polat M., Takeshima S-n., Aida Y. , “Epidemiology and genetic diversity of bovine leukemia virus” Virology Journal; 14:209, DOI: 10.1186/s12985-017-0876-4
２）総説
Meripet Polat, Shin-nosuke Takeshima, Yoko Aida. “Epidemiology and genetic diversity of bovine leukemia virus”, Virology Journal, 14:209, 2017
間陽子、竹嶋伸之輔: BLV診断の新基準～BLV-CoCoMo-qPCR法～. MPアグロジャーナル 28(1):4-7, 2017
竹嶋伸之輔、綿貫園子、間陽子: 牛白血病対策の新技術に迫る（最終回）直接血液からBLVプロウイルスを検出できるBLV-CoCoMo-direct-PCR法と新しい牛白血病制圧戦略、臨床獣医、35(1):26-31, 2017
間陽子：大隅博士とオートファージ、JSAVBR ニュースレター、15号、1～2項、2017
Meripet POLAT、LanLan BAI、竹嶋伸之輔、間陽子：ウシ白血病ウィルスの世界における遺伝的多様性、日本遺伝育種学会誌、45(2)、59～79項、2017
間陽子：特集 牛白血病ウイルス(BLV)に対する理研の挑戦、巻頭言、獣医畜産新報、第70巻、第12号、885頁、2017
大附寛幸、間陽子、竹嶋伸之輔、松浦遼介：特集 牛白血病ウイルス(BLV)に対する理研の挑戦、BLVの分子生物学、獣医畜産新報、第70巻、第12号、896-893頁、2017
白らんらん、佐藤洋隆、綿貫園子、竹嶋伸之輔、間陽子: 特集 牛白血病ウイルス(BLV)に対する理研の挑戦、BLVの診断法の確立 獣医畜産新報、第70巻、第12号、894-900 頁、2017
間陽子、竹嶋伸之輔、陸拾七：特集 牛白血病ウイルス(BLV)に対する理研の挑戦、BLV抵抗性・感受性の診断技術と新しい牛白血病制圧戦略獣医畜産新報、第70巻、第12号、901-908 頁、2017
竹嶋伸之輔、大附寛幸、白らんらん、間陽子：牛白血病ウイルス(BLV)に対する理研の挑戦、BLVのワクチン開発、獣医畜産新報、第70巻、第12号、909-916頁、2017
３）特許出願
発明の名称：ウシ白血病ウイルス（BLV）プロウイルスロードの判定方法とその利用
発明者：間陽子、竹嶋伸之輔、佐々木眞二、杉本喜憲
出願番号：2017-017882号
出願日：2017/2/2
出願人：理化学研究所
発明の名称：遺伝子発現用核酸構築物、およびその利用
発明者：間陽子、大附寛幸、野呂太一、永井泰子
出願番号：2017-144892
出願日：2017/7/26
出願人：理化学研究所
４）受賞
氏名：綿貫 園子
年月：2017年11月
学術集会：日本動物遺伝育種学会第18回大会
賞名：学会長特別賞
演題名：「乳汁中における牛白血病ウイルスの検出と疾患感受性との相関性およびLuSIA法による乳汁中細胞の感染性評価」
＜2016年＞
１）原著論文
Polat M., Takeshima S-n., Hosomichi K., Kim J., Miyasaka T., Yamada Y., Arainga M., Murakami T., Matsumoto Y., Diaz V B., Panei CJ., Gonzalez ET., Barra D V., Panei CJ., Gonzaleze ET., Kanemaki M., Onuma M., Giovambattista G., Aida Y.*, “A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis” Retorovirology; 13:4, DOI: 10.1186/s12977-016-0239-z
Kakisaka M., Mano T. and Aida Y.*, “A high-throughput screening system targeting the nuclear export pathway via the third nuclear export signal of influenza A virus nucleoprotein” Virus Res.; 217, 23?31, DOI: 10.1016/j.virusres.2016.02.007
Takeshima S-n., Watanuki S., Ishizaki H., Matoba K., Aida Y.*, “Development of a direct blood-based PCR system to detect BLV provirus using CoCoMo primers” Arch. Virol.; 161(6):1539-46, DOI: 10.1007/s00705-016-2806-y
Miyatake H.*, Sanjoh A., Murakami T., Murakami H., Matsuda G., Hagiwara K., Yokoyama M., Sato H., Miyamoto Y., Dohmae N. and Aida Y.*, “Molecular Mechanism of HIV-1 Vpr for Binding to Importin-α.” JMB.; 428(13):2744-57, DOI: 10.1016/j.jmb.2016.05.003
Kakisaka M., Yamada K., Yamaji-Hasegawa A., Kobayashi T. and Aida Y.*, “Intrinsically disordered region of influenza A NP regulates viral genome packaging via interactions with viral RNA and host PI(4,5)P2” Virology.; 496:116-26, DOI: 10.1016/j.virol.2016.05.018
Nopporn Chutiwitoonchai, and Aida Y.*, “NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway” Viruses; 8, 209, DOI: 10.3390/v8080209
Makino A, Abe M, Ishitsuka R, Murate M, Kishimoto T, Sakai S, Hullin-Matsuda F, Shimada Y, Inaba T, Miyatake H, Tanaka H, Kurahashi A, Pack CG, Kasai RS, Kubo S, Schieber NL, Dohmae N, Tochio N, Hagiwara K, Sasaki Y, Aida Y, Fujimori F, Kigawa T, Nishibori K, Parton RG, Kusumi A, Sako Y, Anderluh G, Yamashita M, Kobayashi T, Greimel P, Kobayashi T. , “A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C” FASEB J. 16(8); 16(8):2156-68, DOI: 10.1096/fj.201500075R
Nopporn Chutiwitoonchai, Siarot L., Takeda E., Shioda T., Ueda M. and Aida Y.*, “HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release” PloS ONE,; 11(9): e0163100., doi: 10.1371/journal.pone.0163100
Matsubara T, Nishii N, Takashima S, Takasu M, Imaeda N, Aiki-Oshimo K, Yamazoe K, Kakisaka M, Takeshima SN, Aida Y, Kametani Y, Kulski JK, Ando A, Kitagawa H. , “Identification and characterization of two CD4 alleles in Microminipigs” BMC Vet Res.; 12(1):222, DOI: 10.1186/s12917-016-0856-8
２）総説
間陽子: 牛白血病ウイルス感受性・抵抗性牛を利用した新しい牛白血病制圧戦略、 MPアグロジャーナル 27(10) 、2016
竹嶋伸之輔、綿貫園子、間陽子：牛白血病対策の新技術に迫る（１）BLV-CoCoMo-qPCR法によるBLVの診断とBLV伝播リスク因子の検索、臨床獣医 34:34-40、2016
竹嶋伸之輔、綿貫園子、間陽子：牛白血病対策の新技術に迫る（２）BLV-CoCoMo-qPCR法によるBLV伝播リスクの評価、臨床獣医 34:30-35、2016
柿坂道範、間陽子: インフルエンザウイルス核タンパク質(NP)を標的とした創薬開発、臨床免疫・アレルギー科、第65巻(6)、583-587、2016
間陽子：革新的技術で牛白血病ウイルスから牛を守る、家畜感染症学会誌、第5巻(2)、pp43-53頁、2016
３）特許出願
発明の名称：牛白血病ウイルス感染動物の特定方法および医薬品組成物
発明者：間陽子、竹嶋伸之輔、バイランラン、大附寛幸、大石英司
出願番号：2016-038319
出願日：2016.2.29
出願人：
発明の名称：ウシ白血病ウイルス感染性の評価方法
発明者：間陽子、佐藤洋隆
出願番号：2016-158231
出願日：2016/8/10
出願人：
＜2015年＞
１）原著論文
Polat M., Aida Y.*, Takeshima S-n., Aniwashi J., Halik M*. , “The diversity of major histocompatibility complex class II DRB1 gene in sheep breeds from Xinjiang, China” Tissue Antigens; 85: 50?57, DOI: 10.1111/tan.12480
Takeshima S-n., Miyasaka T., Matsumoto Y., Xue G., Diazb V. B., Rogberg-Munozc A., Giovambattista G., Ortiz Ld. M., Oltrad J., Kanemaki M., Onuma M., Aida Y.*, “Assessment of biodiversity in Chilean cattle using the distribution of major histocompatibility complex class II BoLA-DRB3 allele” Tissue Antigens; 85(1):35-44, DOI: 10.1111/tan.12481
Polat M., Ohno A., Takeshima S-n., Kim J., Kikuya M., Matsumoto Y., Mingala C. N., Onuma M., Aida Y.*, “Detection and molecular characterization of bovine leukemia virus in Philippine cattle.” Arch. Virol.; 160:285?296, DOI: 10.1007/s00705-014-2280-3
Takeshima S-n., Kitamura-Muramatsu Y., Yuan Y., Saito S., Aida Y.*, “BLV-CoCoMo-qPCR-2: improvements to the BLV-CoCoMo-qPCR assay for bovine leukemia virus by reducing primer degeneracy and constructing an optimal standard curve.” Arch. Virol.; 160:1325?1332, DOI: 10.1007/s00705-015-2377-3
Miyatake H.*,, Sanjoh A., Unzai S., Matsuda G., Tatsumi Y., Miyamoto Y., Dohmae N. Aida Y.*, “Crystal Structure of Human Importin-α1 (Rch1), Revealing a Potential Autoinhibition Mode Involving Homodimerization.” PloS One; 10(2): e0115995, DOI: 10.1371/journal.pone.0115995
Kakisaka M., Sasaki Y., Yamada K., Kondoh Y., Hikono H, Osada H., Tomii K, Saito T., and Aida Y.*, “A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein” PloS Pathogen.; 11(7):e1005062, DOI: 10.1371/journal.ppat.1005062
Zahoor M. A., Xue G., Sato H., Aida Y.*, “Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells” Virus Res.; 208:156?163, DOI: 10.1016/j.virusres.2015.06.017
Yuan Y., Kitamura-Muramatsu Y., Saito S., Ishizaki H., Nakano M, Haga S, Matoba K., Ohno A, Takeshima S-n, and Aida Y.*, “Detection of the BLV provirus from nasal secretion and saliva samples using BLV-CoCoMo-qPCR-2: Comparison with blood samples from the same cattle” Virus Res.; 210: 248?254, DOI: 10.1016/j.virusres.2015.08.013
Ohno A, Takeshima S-n, Matsumoto Y, and Aida Y.*, “Risk factors associated with increased bovine leukemia virus proviral load in infected cattle in Japan from 2012 to 2014” Virus Res.; 210:283-290, DOI: 10.1016/j.virusres.2015.08.020
Bai L., Takeshima S-n., Isogai E., Kohara J., Aida Y.*, “Novel CD8(+) cytotoxic T cell epitopes in bovine leukemia virus with cattle” Vaccine; 33:7194-7202, DOI: 10.1016/j.vaccine.2015.10.128
Bai L., Hiroyuki O., Hirotaka S, Kohara J., Isogai E, Takeshima S-n., Aida Y.*, “Identification and characterization of common B cell epitope in bovine leukemia virus via high-throughput peptide screening system in infected cattle” Retrovirology; 12(1):106, DOI: 10.1016/j.vaccine.2015.10.128
Takeshima S-n., Giovambattista G., Okimoto N., Matsumoto Y., Rogberg-Munoz A., Acosta T. J., Onuma M., Aida Y.*, “Characterization of bovine MHC class II DRB3 diversity in South American Holstein cattle populations” Tissue Antigens; 86(6):419-30, DOI: 10.1111/tan.12692
Hagiwara K., Ishii H., Murakami T., Takeshima S-n., Chutiwitoonchai N., Kondoh Y., Honda K., Osada H., Tsunetsugu-Yokota Y., Suzuki M., and Aida Y.*, “Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor” PloS ONE.; 10(12):e0145573, DOI: 10.1371/journal.pone.0145573
Bai L., Takeshima S-n., Isogai E., Aida Y., “Peptide microarray mapping of B cell epitopes on bovine leukemia virus and peptide ELISA analysis of conservation of epitopes in BLV infected Japanese cattle” Retorovirology; 12(Suppl 1); 97, DOI https://doi.org/10.1186/1742-4690-12-S1-P97
Takeshima S-n., Bai L., He P., Matsumoto Y., Kohara J., Hirai T., Omori T., Nunoya T., Yamamoto Y., Hidaka T., Togamura K., Matoba K., Aida Y., “A novel bovine leukemia virus peptide vaccine targeting susceptible cattle-Estimating vaccine effectiveness using susceptible cattle constructed by fertilized ovum transplantation” Retorovirology; 12(Suppl 1); 50, DOI https://doi.org/10.1186/1742-4690-12-S1-P50
Bai L., Takeshima S-n., Ohno A., Matsumoto Y., Isogai E., Kohara J., Aida Y., “Epitope mapping of CD8+ T cells on bovine leukemia virus Gag, Env and Tax protein in cattle with different bovine MHC DRB3 alleles” Retorovirology; 12(Suppl 1); 49, DOI https://doi.org/10.1186/1742-4690-12-S1-P49
Aida Y., Kim J., Okimoto N., Yamagishi J., Tada S., Ito Y., Takeshima S-n., “A novel bovine leukemia virus peptide vaccine targeting susceptible cattle-Production by 3-D modelling and nanotechnology” Retorovirology; 12(Suppl 1); 48, DOI https://doi.org/10.1186/1742-4690-12-S1-P48
Otsuki H., Takeshima S-n., Aida Y., “Generation of virus-like particle as a vaccine strategy against bovine leukemia virus” Retorovirology; 12(Suppl 1); 47, doi: 10.1186/1742-4690-12-S1-P47
Ohno A., Takeshima S-n., Kikuya M., Matsumoto Y., Aida Y., “Epidemiological features of BLV infection in Japan from 2012 to 2013” Retorovirology; 12(Suppl 1); 41, DOI https://doi.org/10.1186/1742-4690-12-S1-P41
２）総説
村上裕信、間陽子: HIV-1 アクセサリータンパク質Vprと宿主因子、臨床免疫・アレルギー科、第63巻(5)、 484-488頁、2015
３）著書
間陽子、竹嶋伸之輔：第6章 獲得免疫における主要組織適合遺伝子複合体（MHC）と抗原提示細胞、獣医免疫学、pp86-99頁、2015
＜2014年＞
１）原著論文
Takeshima S-n., Miyasaka T., Polat M., Kikuya M., Matsumoto Y., Mingala C. N., Villanueva M. A., Salces A. J., Onuma M., and Aida Y.*, “The great diversity of major histocompatibility complex class II genes in Philippine native cattle” Meta Gene; 2:176?190, DOI: 10.1016/j.mgene.2013.12.005
Murakami T., and Aida Y.*, “Visualizing Vpr-Induced G2 Arrest and Apoptosis” PloS One; 9(1):e86840, DOI: 10.1371/journal.pone.0086840
Goszczynski D.E., Ripoli M.V., Takeshima S-n., Baltian L., Aida Y., Giovambattista G. , “Haplotype determination of the upstream regulatory region and the second exon of the BoLA-DRB3 gene in Holstein cattle.” Tissue Antigens; 83:180?183, https://doi.org/10.1111/tan.12293
Sasaki Y., Kakisaka M, Chutiwitoonchai M., Tajima S., Hikono H., Saito T., Aida Y.*, “Identification of a novel multiple kinase inhibitor with potent antiviral activity against influenza virus by reducing viral polymerase activity” Biochem. Biophys. Res. Commun.; 450: 49?54, DOI: 10.1016/j.bbrc.2014.05.058
Chutiwitoonchai N., Kakisaka M., Yamada K., Aida Y.*, “Comparative Analysis of Seven Viral Nuclear Export Signals (NESs) Reveals the Crucial Role of Nuclear Export Mediated by the Third NES Consensus Sequence of Nucleoprotein (NP) in Influenza A Virus Replication” PLoS One; 9(8): e105081, DOI: 10.1371/journal.pone.0105081
Zahoor M. A., Xue G., Sato H., Murakami T., Takeshima S-n., Aida Y.*, “HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages” PloS One; 9(8):e106418, DOI: 10.1371/journal.pone.0106418
He Pan., Takeshima S-n., Tada S., Akaike T., Ito Y. Aida Y.*, “pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity” Vaccine; 32: 6199-6205, DOI: 10.1016/j.vaccine.2014.09.032
Aida Y., Takeshima S-n., Panei C., Omori T., Nunoya T., Davis C. W., Ishizaki H., Matoba K., , “BLV-CoCoMo-qPCR: estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis” Retrovirology; 11(Suppl 1): 143, https://doi.org/10.1186/1742-4690-11-S1-P143
２）総説
竹嶋伸之輔、間陽子：ウシMHCクラスⅡ遺伝子の多様性と疾患感受性（Diversity of bovine MHC class II gene）、日本遺伝育種学会誌、第42巻、25-37頁、2014
竹嶋伸之輔、間陽子：ウシMHCクラスⅡ DQA1遺伝子の多様性 (Diversity of bovine MHC class II DQA1 gene)、日本主要適合性学会誌、第21巻、119-129頁、2014
３）著書
Aida Y., Takeshima S-n., Baldwin C. L., and Kaushik A. K., “Bovine Immunogenetics“, THE GENETICS OF CATTLE 2nd Edition (Edited by: Dorian J. Garrick and Anatoly Ruvinsky), “CAB International, pp153-191, 2014
4）受賞
氏名：島田圭悟、平畠淳、長田貴、大坪岳彦、末政 奈津美、間陽子、竹嶋伸之輔
年月：2014.4.24
賞名：第55回全国家畜保健衛生業績発表会 「農林水産省消費・安全局長賞」
「牛白血病対策における本病抵抗性遺伝子利用への一考察」
＜2013年＞
１）原著論文
富田啓介 , 中条正樹 , 加茂前優花 , 塚本洋 , 柴折浩幸 , 岡畑一幸 , 矢島和枝 , 浦本京也 , 竹嶋伸之輔 , 間 陽子, “ホルスタイン種における牛白血病の病態及び発症要因の検討” J. Japan Vet. Medical Sci.; 2 (66): 109-114
Miyasaka T., Takeshima S-n., Jimba M., Kobayashi N., Matsuhashi T., Matsumoto Y., Sentsui H., and Aida Y.*, “Identification of bovine leukocyte antigen class II haplotypes associated with variations in bovine leukemia virus proviral load in Japanese Black cattle” Tissue Antigens; 81:72-82, DOI: 10.1111/tan.12041
Giovambattista G.*, Takeshima S-n., Ripoli M. V., Matsumoto Y., Franco L. A. A., Saito H., Onuma M., Aida Y.*, “Characterization of bovine MHC DRB3 diversity in Latin American Creole cattle breeds ” Gene; 519, DOI: 10.1016/j.gene.2013.01.002
Sasaki Y., Hagiwara K., Kakisaka M., Yamada K., Murakami T., and Aida Y.*, “Importin α3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function ” PLoS ONE; 8(1):e55765, DOI: 10.1371/journal.pone.0055765
Panei C. J., Takeshima S-n., Omori T., Nunoya T., Davis W. C., Ishizaki H., Matoba K., and Aida Y.*, “Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV-CoCoMo-qPCR” BMC Vet. Res.; 9:95, DOI: 10.1186/1746-6148-9-95
２）総説
Aida Y., Murakami H., Takahashi M. and Takeshima S-n. “Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus”, Front. Microbiol., 4: 328, 2013
３）特許出願
発明の名称：新規なポリペプチドとその応用
発明者：間陽子、竹嶋伸之輔、バイランラン
出願番号：2013-67683
出願日：2013.03.27
出願人：
4）受賞
氏名：藤田達男、倉原貴美、安達 聡、竹嶋伸之輔、松本有生、間 陽子
年月：2013.10.13
賞名：日本産業動物獣医学会 ｢九州地区学会長賞｣
「ウシMHC遺伝子マーカーを指標とした牛白血病発症抵抗性遺伝子保有黒毛和種種雄牛の造成」
氏名：山本祐輔、日高健雅、森本和秀、尾形康弘、山本博道、間陽子、竹嶋伸之輔、松本有生
年月：2013.10.16
賞名：平成25年度獣医学術中国地区学会
「地方病性牛白血病における垂直感染状況の実態について」
＜2012年＞
１）原著論文
Ishii H., Koyama H., Hagiwara K., Miura T., Xue G., Hashimoto Y., Kitahara G., and Aida Y, and Suzuki M, , “Synthesis and biological evaluation of deoxy-hematoxylin derivatives as a novel class of anti-HIV-1 agents” Bioorg Med Chem Lett.; 22:1469-1474, DOI: 10.1016/j.bmcl.2011.06.066
Arainga M., Takeda E., and Aida Y.*, “Identification of bovine leukemia virus tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis” BMC Genomics; 13:121, DOI: 10.1186/1471-2164-13-121
Arainga M., Murakami H., and Aida Y.*, ” Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis” BMC Genomics; 13:275, DOI: 10.1186/1471-2164-13-275
Xue G., Aida Y., Onodera T., and Sakudo A. , “The 5′ flanking region and intron1 of the bovine prion protein gene (PRNP) are responsible for negative feedback regulation of the prion protein” PLoS One; 7(3): e32870, DOI: 10.1371/journal.pone.0032870
Yamada K., Koyama H., Hagiwara K., Ueda A., Sasaki Y., Kanesashi S-n., Ueno R., Nakamura H., Kuwata K., Shimizu K., Suzuki M., and Aida Y.*, “Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase” Microbes Infect.; 14:740-747, DOI: 10.1016/j.micinf.2012.02.012
Baltian L., Ripoli M., Sanfilippo S., Takeshima S-n., Aida Y., and Giovambattista G. , “Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina” Molecular Biology Reports; 39:7215?7220, DOI: 10.1007/s11033-012-1526-y
Hebishima T., Yuba E., Kono K., Takeshima S-n., Ito Y., and Aida Y.*, “The pH-sensitive fusogenic 3-methyl-glutarylated hyperbranched poly(glycidol)-conjugated liposome induces antigen-specific cellular and humoral immunity” Clin. Vaccine Immunol.; 19(9):1492-1498, DOI: 10.1128/CVI.00273-12
Jimba M., Takeshima S-n., Kohara J., Kobayashi N., Matsuhashi T., Omori T., Nunoya T. and Aida Y.*, “BLV-CoCoMo-qPCR: a useful tool for evaluating bovine leukemia virus infection status ” BMC Vet. Res.; 8:167, DOI: 10.1186/1746-6148-8-167
Kadengodlu P. A., Hebishima T., Takeshima S-n., Ito M., Liu M., Abe H., Aida Y., Aigaki T., Ito Y. , “Synthesis of Positivelyor Negatively Charged Cholesterol- Recombinant Human Gelatins for the Cellular Uptake of Proteins and Immune Reactions” Int. J. Nanomedicine; 7:5437-5450
２）総説
竹嶋伸之輔、金智潤、蛇島武久、萩原恭二、松本有生、多田誠一、Pallavi Ananda Kadengodlu、伊藤嘉浩、沖本憲明、山岸純也、弓場英司、河野健司、大森崇司、布谷鉄夫、的場和弘、間陽子：JSAVBR NEWS letter, 6, 7-9, 2012
３）著書
Aida Y., Sasaki Y., and Hagiwara K. “Discovery of Novel Antiviral Agents Directed Against the Influenza A Virus Nucleoprotein“, Antiviral Drugs – Aspects of Clinical Use and Recent Advances (Edited by: Patrick Arbuthnot), InTech, pp99-120, 2012
４）特許
発明の名称：ウシ白血病ウイルス検出用プライマーセット、及びその利用
発明者：間陽子、竹嶋伸之輔、神馬繭子、河原紀三郎、斎藤督、村松祐里、袁媛
出願番号：2012-179972
出願日：2012.8.14
出願人：
5）受賞
氏名：竹嶋 伸之輔、的場 和弘、萩原 恭二、金 智潤、山岸 純也、Davis William、大森 崇司、 布谷 鉄夫、沖本 憲明、間 陽子
年月：2012 9.15-17
賞名：第21回日本組織適合性学会大会、｢2012年度大会長賞｣
｢ウシレトロウイルスによる白血病発症を規定する感受性MHCアリルに対するGagおよびEnv由来ペプチドのエピトープマッピング｣
氏名：山岸 純也、沖本 憲明、竹嶋 伸之輔、金 智潤、萩原 恭二、間 陽子、泰地 真弘人
年月： 2012.9.15-17
賞名：第21回日本組織適合性学会大会 ｢2012年度大会長賞｣
｢インシリコ手法によるウシMHCクラスII分子を標的とする抗BLV高親和性ペプチドワクチンの設計｣
＜2011年＞
１）原著論文
Takeshima S-n., Matsumoto Y, Miyasaka T, Arainga-Ramirez M, Saito H, Onuma M and Aida Y.*, “A new method for typing bovine major histocompatibility complex class II DRB3 alleles by combining two established PCR sequence-based techniques” Tissue Antigens; 78:208-213, DOI: 10.1111/j.1399-0039.2011.01708.x
Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T., Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y.*, “Identification and diversity of bovine major histocompatibility complex class II haplotypes in Japanese Black and Holstein cattle in Japan” J.Dairy Sci.; 95:420-31, DOI: 10.3168/jds.2011-4621
Hebishima T., Tada S., Takeshima S-n., Akaike T., Ito Y., and Aida Y.*, “Induction of antigen-specific cellular and humoral immunity by pH-sensitive carbonate apatite” Biochem. Biophys. Res. Commun.; 415:597-601, DOI: 10.1016/j.bbrc.2011.10.114
Aida Y.*, Takeshima S-n., Matsumoto Y., Miyasaka T., Miyazaki Y., Tanabe Y., Davis W.C., and Okada K. , “Bovine MHC class II DR molecule plays a key role in bovine leukemia virus (BLV)-induced lymphoma” Retrovirology; (Suppl 1)
Jimba M., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T., Kohara J., and Aida Y.*, “BLV-CoCoMo-qPCR: comparison of other detection methods for BLV infection and kinetics analysis in experimental transmission of BLV in cattle ” Retrovirology; (Suppl 1)
Arainga-Ramirez M., Takeda E., and Aida Y.*, “Regulation of host cellular gene transcription by Bovine Leukemia Virus (BLV) Tax, wild type and mutants.” Retrovirology; (Suppl 1)
Arainga-Ramirez M., and Aida Y.*, “Imaging and microarray analyses of cell cycle arrest and apoptosis by Human T cell Leukemia Virus type 1 (HTLV-1) Tax” Retrovirology; (Suppl 1)
Takeda E., Matsuda G., Murakami T., Zako T., Maeda M., and Aida Y.*, “Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr” PLoS One; 6(11): e27815, DOI: 10.1371/journal.pone.0027815
２）総説
間陽子、竹嶋伸之輔：牛白血病の世界における感染拡大の現状と防御対策、獣医畜産新報、第64巻、115-120頁、2011
間陽子、竹嶋伸之輔：牛白血病ワクチンの開発と新しい疾病防御戦略、臨床獣医、第29巻、23-29頁、2011
３）著書
間陽子：組織適合抗原、獣医微生物学第３版（見上彪編）、文永堂出版、335-338頁、2011
４）特許出願
発明の名称：BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm
発明者：Aida Y., Takeshima S-n., Jimba M., Endoh D.
出願番号：61/405433
出願日：2011.10.21
出願人：
＜2010年＞
１）原著論文
Hagiwara K., Kondoh Y., Ueda A., Yamada K., Goto H., Watanabe T., Nakata T., Osada H., Aida Y.*, “Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays” Biochem. Biophys. Res. Commun.; 394: 721-727, DOI: 10.1016/j.bbrc.2010.03.058
Hagiwara K., Murakami T., Xue G., Shimizu Y., Takeda E., Hashimoto Y., Honda K., Kondoh Y., Osada H., Tsunetsugu-Yokota Y., Aida Y.*, “Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array” Biochem. Biophys. Res. Commun.; 403:40-45, DOI: 10.1016/j.bbrc.2010.10.107
Jimba M., Takeshima S-n., Matoba K., Endoh D., Aida Y.*, “BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm” Retroviology; 7:91, DOI: 10.1186/1742-4690-7-91
Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T., Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y.*, “The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan” Gene; 472: 42-49, DOI: 10.1016/j.gene.2010.10.007
２）総説
Xue G. and Aida Y. “Discovery of a small molecule inhibitor of the interaction between HIV-1 proteins and cellular cofactors: a novel candidate anti-HIV-1 drug”. Current Chemical Biology, 4: 188-199, 2010
4）受賞
氏名：Shin-Nosuke TAKESHIMA, Yoko AIDA
年月：2010年3月28日
賞名：第112回日本畜産学会「優秀論文賞Excellent Paper Award」
「Structure, function and disease susceptibility of the bovine major histocompatibility complex」Animal Science Journal 77, 138-150 (2006) Shin-Nosuke TAKESHIMA, Yoko AIDA
氏名：間 陽子
年月：2010年9月8日
賞名：Philippine Carabao Center Award
「Meckanisum of lekemogenesis induced by bovine leukemia virus」Yoko AIDA
＜2009年＞
１）原著論文
Takeshima S-n., Matsumoto Y., and Aida Y.*, “Short communication: Establishment of a new polymerase chain reaction-sequence-based typing method for genotyping cattle major histocompatibility complex class II DRB3” J. Dairy Sci.; 92:2965-2970, https://doi.org/10.3168/jds.2008-1999
Takeshima S-n., Sarai Y., Saito N., and Aida Y.*, “MHC class II DR classification based on antigen-binding groove natural selection” Biochem Biophys Res Commun.; 385:137-142, DOI: 10.1016/j.bbrc.2009.04.142
Yoshida T., Mukoyama H., Furuta H., Kondo Y., Takeshima S-n., Aida Y., Kosugiyama M., and Tomogane H. , “Association of the amino acid motifs of BoLA-DRB3 alleles with mastitis pathogens in Japanese Holstein cows” Anim Sci J.; 80:510-519, DOI: 10.1111/j.1740-0929.2009.00664.x
Yoshida T., Mukoyama H., Furuta H., Kondo Y., Takeshima S-n., Aida Y., Kosugiyama M., and Tomogane H. , “Association of BoLA-DRB3 alleles identified by a sequence-based typing method with mastitis pathogens in Japanese Holstein cows” Anim Sci J.; 80:498-509, DOI: 10.1111/j.1740-0929.2009.00663.x
Nonaka M., Hashimoto Y., Takeshima S-n., and Aida Y.*, “The human immunodeficiency virus type 1 Vpr protein and its carboxy-terminally truncated form induce apoptosis in tumor cells” Cancer Cell Int.; 9:20, DOI: 10.1186/1475-2867-9-20
Suzuki T., Yamamoto N., Nonaka M., Takeshima S., Hashimoto Y., Matsuda G., Matsuyama M., Igarashi T., Miura T., Tanaka R., Kato S., and Aida Y.*, “Inhibition of human immunodeficiency virus type 1 (HIV-1) nuclear import via Vpr-Importin alpha interactions as a novel HIV-1 therapy” Biochem. Biophys. Res. Commun.; 380:838-843, DOI: 10.1016/j.bbrc.2009.01.180
２）総説
Aida Y. and Matsuda G. “Role of Vpr in HIV-1 nuclear import; therapeutic implications”, Current HIV-1 Research, 7：136-143, 2009
Zhang X. and Aida Y.：“HIV-1 Vpr: a novel role in regulating RNA splicing”, Current HIV-1 Research, 7: 163-168, 2009.
間陽子：インポーチンαを介したヒト免疫不全ウイルス1型Vprの核移行、生化学、第81巻、720-725頁、2009
３）特許
発明の名称：Vprタンパク質の検出方法及び検出用試薬
発明者：間陽子、鈴木正昭、石井英樹、鈴木辰徳、松田剛
出願番号：2009-158179
出願日：2009.7.2
出願人：
＜2008年＞
１）原著論文
Takeshima S-n., Chen J., Miki A., Kado M., and Y. Aida. “Distribution and origin of bovine major histocompatibility complex class II DQA1 genes in Japan”. Tissue Antigens, 72:195-205, 2008. PMID: 18715338 DOI: 10.1111/j.1399-0039.2008.01092.x
Takeshima S-n, Matsumoto Y., Chen J., Yoshida T., Mukoyama H., and Y. Aida. “Evidence for cattle major histocompatibility complex (BoLA) class II DQA1 gene heterozygote advantage against clinical mastitis caused by Streptococci and Escherichia species”. Tissue Antigens, 72: 525–531, 2008. PMID: 19000149 DOI: 10.1111/j.1399-0039.2008.01140.x
２）総説
間陽子 *：ヒト免疫不全ウイルス 1 型 Vpr によるスプライシング制御、生体の科学、第59 巻、380-381 頁、2008
＜2007年＞
１）原著論文
Takeshima S-n., Chen J., Sato M., and Aida Y*. “Relationship Between Polymorphism of BoLA Class IIa Region and Resistance for Development of Bovine Leukemia Virus (BLV)-induced Lymphoma”. AIDS Research and Human Retroviruses,, 23(4): 624, 2007
Aida Y*., and Inabe K. “Syncytium-forming Ability and Expression on the Cell Surface of Bovine Leukemia Virus Envelope Glycoprotein Are Regulated by YXXL Motif of Transmembrane subunit”. AIDS Research and Human Retroviruses, 23(4): 647, 2007
Mwangi W., Brown W. C., Splitter G. A., Davies C. J., Howard C.J., Hope J. C., Aida Y., Zhuang Y., Hunter B. J., and Palmer G. H. “DNA vaccine construct incorporating intercellular trafficking and intracellular targeting motifs effectively primes and induces memory B- and T-cell responses in outbred animals”. Clin. Vaccine Immunol., 14: 304-311, 2007PMID: 17215335 PMCID: PMC1828862 DOI: 10.1128/CVI.00363-06
Nitahara-Kasahara Y., Kamata M., Yamamoto T., Zhang X., Miyamoto Y., Muneta K., Iijima S., Yoneda Y., Tsunetsugu-Yokota Y. and Aida Y*. “Novel nuclear import of Vpr promoted by importinαis crucial for human immunodeficiency virus type 1 replication in macrophages”. J. Virol., 81:5284-5293, 2007. PMID: 17344301 PMCID: PMC1900242 DOI: 10.1128/JVI.01928-06
Hashizume C., Kuramitsu M., Zhang X., Kurosawa T., Kamata M. and Aida Y*. “Human immunodeficiency virus type 1 Vpr interacts with spliceosome-associated protein 145 to mediate cellular pre-mRNA splicing inhibition”, Microbes Infect., 9:490- 497, 2007. PMID: 17347016 DOI: 10.1016/j.micinf.2007.01.013
Takeshima S-n., Miki A., Kado M., and Aida Y*. “Establishment of a sequence-based typing system for BoLA-DQA1 exon 2”. Tissue Antigens, 69: 189-199, 2007. PMID: 17257323 DOI: 10.1111/j.1399-0039.2006.00751.x
２）総説
竹嶋伸之輔、間陽子*：「特集 : 動物 MHC」ウシ主要組織適合遺伝子複合体(BoLA) と疾患感受性、アニテックス、第 19 巻、18-26 頁、2007
竹嶋伸之輔、間陽子*：「ミニレビュー」ウシ主要組織適合遺伝子複合体 (BoLA) 領域の多様性と抗病性、動物遺伝育種研究会誌、第 35 巻、51-64 頁、2007
竹嶋伸之輔、間陽子*：ウシ主要組織適合遺伝子複合体(BoLA) の構造・機能・進化と疾 患感受性、「シリーズ：MHC の比較ゲノム」、日本組織適合性学会誌、第 14 巻、9-22 頁、 2007
間陽子 *：レトロウイルスの核移行、蛋白質核酸酵素、「増刊号 ウイルス研究の現在と展望」、第 52 巻、1214-1220 頁、2007
間陽子 *、竹嶋伸之輔：白血病と乳房炎感受性と牛主要組織適合(BoLA) の遺伝的多様性、
「特集：主要組織適合抗原(MHC) と疾患解析の最前線 ―臨床応用への展望―」、獣医畜産新報、第 60 巻、11 号、925-927 貢、2007
間陽子 *：学会・研究会紹介⑰ 動物 MHC 研究会、SAC (Small Animal Clinic) 小動物獣医学情報誌 第 149 巻、裏表紙、2007
＜2006年＞
１）原著論文
Azuma A., Matsuo A., Suzuki T., Kurosawa T., Zhang X. and Aida Y*. “Human immunodeficiency virus type 1 Vpr induces cell cycle arrest at the G1 phase and apoptosis via disruption of mitochondorial function in rodent cells”. Microbes Infect., 8:670-679, 2006. PMID: 16480911 DOI: 10.1016/j.micinf.2005.09.002
２）総説
Takeshima S. and Aida Y*. “Structure, function, and disease susceptibility of the bovine major histocompatibility complex”, Animal Science J., 77:138-250, 2006.
＜2005年＞
１）原著論文
Takahashi M., Tajima S., Okada K., Davis W.C, and Aida Y*. “Involvement of Bovine Leukemia Virus Tax in Induction and Inhibition of Apoptosis”, Microbes Infect., 7:19- 28, 2005. PMID: 15716078 DOI: 10.1016/j.micinf.2004.09.014
Kamata M., Nitahara-Kasahara Y., Miyamoto Y., Yoneda Y., and Aida Y*. “Importin-α promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr”. J. Virol., 79:3557-3564, 2005. PMID: 15731250 PMCID: PMC1075686 DOI: 10.1128/JVI.79.6.3557-3564.2005
Kuramitsu M., Hashizume C., Yamamoto, N, Azuma A., Kamata M., Yamamoto, N, Tanaka Y., and Aida Y*. “A novel role for Vpr of human immunodeficiency virus type 1 as a regulator of the splicing of cellular pre-mRNA”. Microbes Infect., 7:1150-1160, 2005. PMID: 15908254 DOI: 10.1016/j.micinf.2005.03.022
Tajima S., and Aida Y*. “Induction of expression of bovine leukemia virus (BLV) in blood taken from BLV-infected cows without removal of plasma”. Microbes Infect., 7:1211-1216, 2005. PMID: 16002314 DOI: 10.1016/j.micinf.2005.04.010
Okada K, Nakae N., Kuramochi K., Yin S., Ikeda M., Takami S, Hirata T., Goryo M., Numakunai S., Takeshima S., Takahashi M., Tajima S., Konnai S., Onuma M., and Aida Y. “Bovine leukemia virus high tax coded molecular clone xperimentally induces leukemia/lymphoma in sheep”. J. Vet. Medical Sci., 67 (11): 1231-1235, 2005. PMID: 16397381 DOI: 10.1292/jvms.67.1231
２）総説
竹嶋伸之輔、間陽子 *：[ シリーズ：異種の MHC] ヒツジのMHC、日本組織適合性学会誌、第 11 巻、179-187 頁、2005
＜2004年＞
１）原著論文
Takahashi M., Tajima S., Takeshima S, Konnai S., Yin S.A., Okada K., Davis W.C. and Aida Y*. “Ex vivo survival of peripheral blood mononuclear cells in sheep induced by bovine leukemia virus (BLV) mainly occurs in CD5-B cells that express BLV”. Microbes Infect., 6:584-595, 2004. PMID: 15158193 DOI: 10.1016/j.micinf.2004.02.014
Iijima S., Nitahara-Kasahara Y., Kimata K., Zhuang W.Z., Kamata M., Isogai M, Miwa M., Yokota-Tsunetsugu Y., and Aida Y*. “Nuclear localization of Vpr is crucial for the efficient replication of HIV-1 in primary CD4+ T cells”. Virology 327:249-261, 2004. PMID: 15351213 DOI: 10.1016/j.virol.2004.06.024
Yamanishi K., Pichl L., Nitahara-Kasahara Y., and Aida Y. “Three dimentional space interaction model for HIV-1 accesory protein Vpr and membrane lipid molecules”, J. Three Dimensional Images, 18:67, 2004.
Pichl L., Yamanishi K., Nitahara-Kasahara Y., and Aida Y. “Molecular dynamics simulation of lipid-protein ensembles”, Int. J. Bioelectromagnetism, 6:35-42, 2004.
２）総説
間陽子 *：牛白血病ウイルスの潜伏化と白血病発症、ミニ特集：見えてきたウイルス発癌、獣医畜産新報、第 57 巻、591-593 貢、2004
＜2003年＞
１）原著論文
Tajima S., Takahashi M., Takeshima S., Konnai S., Yin S. A., Watarai S., Tana, Tanaka Y., Onuma M., Okada K., and Aida Y*. “A mutant form of the Tax protein of bovine leukemia virus (BLV), with enhanced transactivation activiy, increases expression and propagation of BLV in vitro but not in vivo”. J. Virol., 77: 1894-1903, 2003. PMID: 12525624 PMCID: PMC140974 DOI: 10.1128/jvi.77.3.1894-1903.2003
Aida Y*, Konnai S., Takeshima S., Tajima S., Yin S. A., Onuma M., and Okada K.. “The influence of polymorphism of MHC class II DRB1 alleles on immune response in bovine leukemia virus infection”. AIDS Research and Human Retroviruses, 19: S41, 2003.
Konnai S., Takeshima S., Tajima S., Yin S. A., Okada K., Onuma M., and Aida Y*. “The influence of ovine MHC class II DRB1 alleles on immune response in bovine leukemia virus infection”. Microbiol. Immunol., 47: 223-232, 2003. PMID: 12725293 DOI: 10.1111/j.1348-0421.2003.tb03391.x
Tajima S., Tsukamoto M., and Aida Y*. “Latency of viral expression in vivo is not related to CpG methylation in the U3 region and part of the R region of the long terminal repeat of bovine leukemia virus”. J. Virol., 77: 4423-4430, 2003. PMID: 12634400 PMCID: PMC150652 DOI: 10.1128/jvi.77.7.4423-4430.2003
Konnai S., Nagaoka Y., Takeshima S., Onuma M., and Aida Y*. “Sequences and diversity of 17 new Ovar-DRB1 alleles from three breeds of sheep”. Eur. J. Immunogenet., 30: 275-282, 2003. PMID: 12919289 DOI: 10.1046/j.1365-2370.2003.00399.x
Konnai S., Nagaoka Y., Takeshima S., Onuma M., and Aida Y*. “DNA typing for ovine MHC DRB1 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)”. J Dairy Sci., 86: 3362-3365, 2003. PMID: 14594256 DOI: 10.3168/jds.S0022-0302(03)73939-3
Takeshima S., Saitou N., Morita M., Inoko H., and Aida Y*. “The diversity of bovine MHC class II DRB3 genes in Japanese Black, Japanese Shorthorn, Jersey and Holstein cattle in Japan”. Gene, 316: 111-118, 2003. PMID: 14563557 DOI: 10.1016/s0378-1119(03)00744-3
Ando A, Kawata H, Shigenari A, Anzai T, Ota M, Katsuyama Y, Sada M, Goto R, Takeshima S. n., Aida Y., Iwanaga T., Fujimura N., Suzuki Y., Gojobori T., and Inoko H. “Genetic polymorphism of the swine major histocompatibility complex (SLA) class I genes, SLA-1, -2 and -3”. Immunogenetics. 55:583-593, 2003. PMID: 14605775 DOI: 10.1007/s00251-003-0619-0
Usui T, Konnai S, Tajima S, Watarai S, Aida Y, Ohashi K and Onuma M. “Protective effects of vaccination with bovine leukemia virus (BLV) Tax DNA against BLV infection in sheep”, J. Vet. Med. Sci., 65:1201-1205, 2003. PMID: 14665749 DOI: 10.1292/jvms.65.1201
２）総説
岡田幸助、尹善愛、池田学、今内覚、田島茂、竹嶋伸之輔、高橋雅彦、平田統一、沼宮 内茂、御領政信、小沼操、間陽子：御明神牧場におけるウシ白血病ウイルス接種実験概要、岩手大学農学部附属寒冷フィールドサイエンス教育研究センター年報、第 1 巻、69-78 貢、 2003
＜2002年＞
１）原著論文
Tajima S. and Aida Y*. “Mutant Tax protein from bovine leukemia virus with enhanced ability to activate the expression of c-fos”, J. Virol., 76: 2557-2562, 2002. PMID: 11836435 PMCID: PMC135937 DOI: 10.1128/jvi.76.5.2557-2562.2002
Takeshima S-n., Nakai Y., Ohta M., and Aida Y*. “Characterization of DRB3 alleles in the MHC of Japanese Shorthorn cattle by polymerase chain reaction-sequence-based typing”. J. Dairy Sci., 85: 1630-1632, 2002.
＜2001年＞
１）原著論文
Takeshima S-n., Ikegami M., Morita M., Nakai Y., and Aida Y*. “Identification of new cattle BoLA-DRB3 alleles by sequence-based typing”. Immunogenetics, 53: 74-81, 2001. PMID: 11261936 DOI: 10.1007/s002510000293
Yasuda J., Miyao T., Kamata M., Aida Y., and Iwakura Y. “T cell apoptosis causes peripheral T cell depletion in mice transgenic for the HIV-1 vpr gene”. Virology, 285: 181-192, 2001. PMID: 11437653 DOI: 10.1006/viro.2001.0964
Tana, Watarai S., Aida Y., Tajima S., Kaikidani H., Onuma M., and Kodama M. “Growth inhibition of cancer cells by co-transfection of diphtheria toxin A-chain gene plasmid with bovine leukemia virus-Tax expression vector”. Microbiol. Immunol., 45: 447-455, 2001. PMID: 11497220 DOI: 10.1111/j.1348-0421.2001.tb02644.x
Tajima S., Takahashi M., Okada K., and Aida Y*. “In vitro and in vivo analyses of infectious molecular clone of BLV encoding tax with elevated transactivation activity”. AIDS Resesch and Human Retroviruses, 17: S48, 2001.
Aida Y*. “Influence of host genetic differences on leukemogenesis induced by bovine leukemia virus”. AIDS Research and Human Retroviruses, 17: S12, 2001.
２）総説
間陽子 *：農学領域におけるゲノムサイエンスの展開 (Part 2)“ ウシゲノム解析と抗病性 [1]”、農業および園芸、養賢堂、第 76 巻、1187-1193 頁、2001
間陽子 *：農学領域におけるゲノムサイエンスの展開 (Part 2)“ ウシゲノム解析と抗病性 [2]”、農業および園芸、養賢堂、第 76 巻、1289-1294 頁、2001
竹嶋伸之輔、中井裕、太田実、間陽子：ウシ主要組織適合抗原のタイピング法、川渡農場報告、第 17 巻、19-28 頁、2001
＜2000年＞
１）原著論文
Nishizawa M., Kamata M., Katsumata R., and Aida Y*. “A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G1 cell cycle arrest”. J. Virol., 74: 6058-6067, 2000. PMID: 10846089 PMCID: PMC112104 DOI: 10.1128/jvi.74.13.6058-6067.2000
Kamata M. and Aida Y*. “Two putative α-herical domains of human immunodeficiency virus type 1 Vpr mediate nuclear localization by at least two mechanisms”. J. Virol., 74: 7179-7186, 2000. PMID: 10888660 PMCID: PMC112238 DOI: 10.1128/jvi.74.15.7179-7186.2000
Nishizawa M., Kamata M., Myojin T., Nakai Y., and Aida Y*. “Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G2 arrest of the cell cycle”. Virology, 276: 16-26, 2000. PMID: 11021990 DOI: 10.1006/viro.2000.0534
Tajima S. and Aida Y*. “The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) Tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers”. J. Virol., 74: 10939-10949, 2000. PMID: 11069988 PMCID: PMC113173 DOI: 10.1128/jvi.74.23.10939-10949.2000
Aida Y., Takeshima S., Nagaoka Y., Ikegami M., Gotoh-Inabe K., Kabeya H., Onuma M., and Okada K. “The relationship between polymorphism of the MHC class II DR gene and resistance and susceptibility to bovine leukemia virus-induced lymphoma”, International Workshop on the potential application of recombinant cytokines and DNA vaccines for the control of infectious diseases of domestic animals, pp159-162, Proceedings of the International Veterinary Cytokine and Vaccine Conference (IVCVC), Tsukuba, Ibaraki, Japan, 2000.
4）受賞
氏名：間 陽子
年月：2000年4月
賞名：平成12年度日本獣医学会賞受賞
「牛白血病ウイルスによる白血病発症の感受性を規定するウシMHCクラスⅡ遺伝子の分子生物学的解析とその臨床応用」間陽子
＜1999年＞
１）原著論文
Inabe K., Nishizawa M., Tajima S., Ikuta K., and Aida Y*. “The YXXL sequences of a transmembrane protein of bovine leukemia virus are required for viral entry and incorporation of viral envelope protein into virions”. J. Virol., 73: 1293-1301, 1999. PMID: 9882334 PMCID: PMC103953 DOI: 10.1128/JVI.73.2.1293-1301.1999
Nagaoka Y., Kabeya H., Onuma M., Kasai N., Okada K., and Aida Y*. “Ovine MHC class II DRB1 alleles associated with resistance or susceptibility to development of bovine leukemia virus-induced ovine lymphoma”. Cancer Res., 59: 975-981, 1999. PMID: 10029093
Kabeya H., Ohashi K., Oyunbileg N., Nagaoka Y., Aida Y., Sugimoto C., Yokomizo Y., and Onuma M. “Up-regulation of tumor necrosis factor αmRNA is associated with bovine-leukemia virus (BLV) elimination in the early phase of infection”. Vet. Immunol. Immunopathol., 68: 255-265, 1999. PMID: 10438324 DOI: 10.1016/s0165-2427(99)00029-x
Nishizawa M., Myojin T., Nishino Y., Nakai Y., Kamata M., and Aida Y*. “A carboxy- terminally truncated form of the Vpr protein of human immunodeficiency virus type 1 retards cell proliferation independently of G2 arrest of the cell cycle”. Virology, 263: 313-322, 1999. PMID: 10544105 DOI: 10.1006/viro.1999.9905
２）総説
田島茂、間陽子*：牛白血病ウイルス誘発性B リンパ腫におけるウシp53 遺伝子の変異、動物遺伝研究会誌、第 27 巻、45-54 頁、1999
間陽子*：免疫応答遺伝子の多型解析を用いた抗病性ウシ作出への基礎的研究、畜産技術、第 17 巻、24-27 頁、1999
＜1998年＞
１）原著論文
Tajima S., Zhuang W., Kato M. V., Okada K., Ikawa Y., and Aida Y*. “Function and conformation of wild-type p53 protein are influenced by mutations in bovine leukemia virus-induced B-cell lymphosarcoma”. Virology, 243: 235-246, 1998. PMID: 9540787
Inabe K., Ikuta K., and Aida Y*. “Transmission and propagation in cell culture of virus produced by cells transfected with an infectious molecular clone of bovine leukemia virus”. Virology, 245: 53-64, 1998. PMID: 9614867 DOI: 10.1006/viro.1998.9140
Tajima S., Ikawa Y., and Aida Y*. “Complete bovine leukemia virus (BLV) provirus is conserved in BLV-infected cattle throughout the course of B-cell lymphosarcoma development”. J. Virol., 72: 7569-7576, 1998. PMID: 9696855 PMCID: PMC110004 DOI: 10.1128/JVI.72.9.7569-7576.1998
Fukumori T., Akari H., Iida S., Hata S., Kagawa S., Aida Y., Koyama H., and Adachi A. “The HIV-1 Vpr displays strong anti-apoptotic activity”. FEBS Letters, 432: 17-20, 1998. PMID: 9710242 DOI: 10.1016/s0014-5793(98)00824-2
Tana, Watarai S., Onuma M., Aida Y., Kakidani H., Kodama H., and Yasuda T. “Antitumor effect of diphtheria toxin A-chain gene-containing cationic liposomes conjugated with monoclonal antibody directed to tumor-associated antigen of bovine leukemia cells”. Jpn. J. Cancer Res., 89: 1202-1211, 1998. PMID: 9914790 PMCID: PMC5921722 DOI: 10.1111/j.1349-7006.1998.tb00516.x
２）総説
間陽子 *：疾患感受性を規定するウシMHC クラスII 分子の構造と機能、動物遺伝研究会誌、第 26 巻、1-12 頁、1998
Aida Y*. Human immunodeficiency virus type 1 vpr gene product prevents cell proliferarion”, RIKEN Review, 18: 37-38, 1998.
＜1997年＞
１）原著論文
Nishino Y., Myojin T., Kamata M., and Aida Y*. “Human immunodeficiency virus type 1 vpr gene product prevents cell proliferation on mouse NIH3T3 cells without the G2 arrest of the cell cycle”, Biochem. Biophys. Res. Commun., 232: 550-554, 1997. PMID: 9125220 DOI: 10.1006/bbrc.1997.6186
Tani K., Asahina M., Wu D. L., Ajito T., Murakami K., Goryo M., Aida Y., Davis W. C., and Okada K. “Further analysis of the phenotype and distribution of tumor cells in sporadic B-cell and T-cell lymphomas in the lymph node and spleen of cattle”. Vet. Immunol. Immunopathol., 55: 283-290, 1997. PMID: 9151400 DOI: 10.1016/s0165-2427(96)05627-9
Aida Y*., Nishino Y., Amanuma H., Murakami K., Okada K., and Ikawa Y. “The role of tumor-associated antigen in bovine leukemia virus-induced lymphosarcoma”, Leukemia, 11: S216-S218, 1997. PMID: 9209345
Zhuang W., Tajima S., Okada K., Ikawa Y., and Aida Y*. “Point mutation of p53 tumor suppressor gene in bovine leukemia virus-induced lymphosarcoma”. Leukemia, 11: S344-S346, 1997. PMID: 9209385
Koguchi A., Goryo M., Aida Y., and Okada K. “Tumor-associated antigen in lymph nodes during the progression of enzootic bovine leucosis”. Leukemia, 11: S221-222, 1997. PMID: 9209347
２）総説
間陽子 *、長岡淑子：ウシMHC 遺伝子、日本組織適合性学会誌、第 3 巻、213-225 頁、1997
間陽子*：ウシ白血病ウイルスによる白血病発症とMHC、獣医臨床遺伝研究会誌、第5-6 巻、14-17 頁、1997
４）受賞
氏名：間 陽子
年月：1997年6月
賞名：平成8年度森永奉仕会受賞
「抗病性遺伝子マーカーおよび腫瘍マーカーとしてのウシ腫瘍組織適合クラスⅡ抗原の解析」
＜1996年＞
１）原著論文
Niimi M., Nakai Y., and Aida Y*. “Identification of bovine invariant chain (Ii) gene bynucleotide sequencing”. Biochem. Biophys. Res. Commun., 222: 7-12, 1996. PMID: 8630076 DOI: 10.1006/bbrc.1996.0689
Komori H., Ishiguro N., Horiuchi M., Shinagawa M., and Aida Y. “Predominant p53 mutations in enzootic bovine leukemic cell lines”. Vet. Immunol. Immunopathol., 52: 53-63, 1996. PMID: 8807776 DOI: 10.1016/0165-2427(95)05538-x
Koguchi A., Chiba T., Hiraga M., Hasuta Y., Tsujimoto T., Furusato K., Goryo M., Davis W. C., Aida Y., and Okada K. “Changes in the distribution of cells expressing tumour-associated antigen in lymph nodes during the progression of enzootic bovine leucosis”. J. Comp. Pathol., 115: 343-352, 1996. PMID: 9004077 DOI: 10.1016/s0021-9975(96)80070-3
Wu D., Takahashi K., Murakami K., Tani K., Koguchi A., Asahina M., Goryo M., Aida Y., and Okada K. “B-1a, B-1b and conventional B cell lymphoma from enzootic bovine leucosis”. Vet. Immunol. Immunopathol., 55: 63-72, 1996. PMID: 9014306 DOI: 10.1016/s0165-2427(96)05631-0
２）総説
間陽子 *：MHC の機能、Associate Doctors and Students、第 2 巻、250-253 頁、1996
＜1995年＞
１）原著論文
Aida Y*., Niimi M., Asahina M., Okada K., Nakai Y., and Ogimoto K. “Identification of a new bovine MHC class II DRB allele by nucleotide sequencing and an analysis of phylogenetic relationships”. Biochem. Biophys. Res. Commun., 209: 981-988, 1995. PMID: 7733993 DOI: 10.1006/bbrc.1995.1594
Dikiniene N., and Aida Y*. “Cattle cDNA clones encoding MHC class II DQB1 and DQB2 genes”. Immunogenetics, 42: 75, 1995. PMID: 7797273 DOI: 10.1007/BF00164992
Morooka A., Asahina M., Kohda C., Tajima S., Niimi M., Nishino Y., Sugiyama M., and Aida Y*. “Nucleotide sequence and the molecular evolution of a new A2 gene in the DQ subregion of the bovine major histocompatibility complex” . Biochem. Biophys. Res. Commun., 212: 110-117, 1995. PMID: 7611993 DOI: 10.1006/bbrc.1995.1943
Nishino Y., Tajima S., and Aida Y*. “Cattle cDNA clone encoding a new allele of the MHC class II DQA1 gene”. Immunogenetics, 42: 306-307, 1995. PMID: 7672829 DOI: 10.1007/BF00176452
Nagata Y., Nagahisa H., Aida Y., Okutomi K., Nagasawa T., and Todokoro K. “Thrombopoietin induces megakaryocyte differentiation in hematopoietic progenitor FDC-P2 cells” . J. Biol. Chem., 270: 19673-19675, 1995. PMID: 7649975 DOI: 10.1074/jbc.270.34.19673
Chiba T., Hiraga M., Aida Y., Ajito T., Asahina M., Wu D., Ohshima K., Davis W. C., and Okada K. “Immunohistologic studies on subpopulations of lymphocytes in cattle with enzootic bovine leucosis”. Vet. Pathol., 32: 513-520, 1995. PMID: 8578642 DOI: 10.1177/030098589503200509
Asahina M., Kimura K., Murakami K., Ajito T., Wu D., Goryo M., Aida Y., Davis W. C., and Okada K. “Phenotypic analysis on neoplastic cells from calf, thymic, and intermediate forms of bovine leucosis”. Vet. Pathol., 32: 683-691, 1995. PMID: 8592804 DOI: 10.1177/030098589503200610
Niimi M., Nakai Y., and Aida Y*. “Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex”. Biochem. Biophys. Res. Commun., 217: 522-528, 1995. PMID: 7503731 DOI: 10.1006/bbrc.1995.2807
Aida Y*. “Characterization and expression of bovine MHC class II genes”. Bull. Soc. Fr.-Jpn. Vet., 6: 17-24, 1995.
＜1994年＞
１）原著論文
Murakami K., Okada K., Amanuma H., and Aida Y*. “The γδT cell population in sheep experimentally infected with bovine leukemia virus”. Vet. Pathol., 31: 103-105, 1994. https://doi.org/10.1177/030098589403100113
Murakami, K., Aida Y*., Kageyama R., Numakunai S., Ohshima K., Okada K., and Ikawa Y. “Immunopathologic study and characterization of the phenotype oftransformed cells in sheep with bovine leukemia virus-induced lymphosarcoma”. Am.J. Vet. Res., 55: 72-80, 1994. PMID: 8141500
Aida Y*., Kohda C., Morooka A., Nakai Y., Ogimoto K., Urao T., and Asahina M. “Cloning of cDNAs and the molecular evolution of a bovine MHC class II DRA gene”. Biochem. Biophys. Res. Commun., 204: 195-202, 1994. PMID: 7945359 DOI: 10.1006/bbrc.1994.2444
２）総説
Aida Y. Tumor-associated antigen that is expressed on bovine leukemia virus-induced lymphosarcoma”, RIKEN Review, 6: 5-6, 1994.
＜1993年＞
１）原著論文
Aida Y*., Okada K., and Amanuma H. “Phenotype and ontogeny of cells carrying a tumor-associated antigen that is expressed on bovine leukemia virus-induced lymphosarcoma”. Cancer Res., 53: 429-437, 1993. PMID: 8380256
Aida Y*., Okada K., and Onuma M. “Antigenic regions defined by monoclonal antibodies on tumor-associated antigens of bovine leukemia virus-induced lymphosarcoma cells”. Leuk. Res., 17: 187-193, 1993. PMID: 7679174 DOI: 10.1016/0145-2126(93)90064-r
Slavikova K., Zajac V., Klobusicka M., Aida Y., and Stevurkova V. “Gp51 of bovine leukemia virus gene expression in hamster cells”. Int. J. Cancer, 53: 640-644, 1993.
Ishiguro N., Aida Y., Shinagawa T., and Shinagawa M. “Molecular structures of cattle T-cell receptor gamma and delta chains predominantly expressed on peripheral blood lymphocytes”. Immunogenetics, 38: 437-443, 1993 PMID: 8406615 DOI: 10.1007/BF00184524
２）総説
間陽子、大石和恵、井川洋二：HTLV-1 のモデルとしてのBLV 実験感染羊の白血病発症 とワクチン開発、AIDS とATL ー分子レベルから予防・治療までー、実験医学、第 11 巻、 5 号（増刊）、547-557 頁、1993
＜1992年＞
１）原著論文
Aida Y*., Okada K., Kageyama R., and Amanuma H. “Cross-reactivity between a monoclonal antibody that recognizes a tumor-associated antigen on bovine lymphosarcoma cells and blood lymphocytes from various mammalian species”. Am. J. Vet. Res., 53: 1988-1991, 1992. PMID: 1466490
Aida Y*., Okada K., Ohtsuka M., and Amanuma H. “Tumor-associated Mr 34,000 and Mr 32,000 membrane glycoproteins that are serine-phosphorylated specifically in bovine leukemia virus-induced lymphosarcoma cells”. Cancer Res., 52: 6463-6470, 1992. PMID: 1330294
＜1991年＞
１）原著論文
Ohshima K., Aida Y., Kim J-C., Okada K., Chiba T., Murakami K., and Ikawa Y. “Histopathology and distribution of cells harboring bovine leukemia virus (BLV) proviral sequences in ovine lymphosarcoma induced by BLV inoculation”. J. Vet. Med. Sci., 53: 191-199, 1991 PMID: 1650599 DOI: 10.1292/jvms.53.191
Okada K., Hosokawa Y., Aida Y., and Ohshima K. “In situ hybridization for the demonstration of bovine leukemia virus transcripts in lymphosarcoma cells using biotinylated probes”. J. Vet. Med., B38: 707-713, 1991. PMID: 1665000 DOI: 10.1111/j.1439-0450.1991.tb00932.x
＜1989年＞
１）原著論文
Aida Y*., Miyasaka M., Okada K., Onuma M., Kogure S., Suzuki M., Minoprio P., Levy D., and Ikawa Y. “Further phenotypic characterization of target cells for bovine leukemia virus experimental infection in sheep”. Am. J. Vet. Res., 50: 1946-1951, 1989 PMID: 2559634
＜1987年＞
１）原著論文
Okada K., Sakaguchi I., Numakunai S., Aida Y., Onuma M., and Ohshima K. “Existence of antigens cross-linking to tumor associated antigens of enzootic bovine leukosis in normal tissues of the bovine fetus”. Jpn. J. Vet. Sci., 49: 373-377, 1987. PMID: 3035262 DOI: 10.1292/jvms1939.49.373
Ochiai K., Aida Y., Fujimoto Y., and Onuma M. “Suppressive effect on tumor growth of enzootic bovine leukemia cells in nude mice by monoclonal antibodies against tumor- associated antigens”. Jpn. J. Vet. Sci., 49: 1065-1072, 1987. PMID: 2828732 DOI: 10.1292/jvms1939.49.1065
Suzuki M., Okada K., Ohshima K., Numakunai S., Aida Y., and Onuma M. “Application of complement-dependent antibody cytotoxicity test for diagnosis of enzootic bovine lymphosarcoma”. Jpn. J. Vet. Sci., 49: 841-846, 1987. PMID: 2824908 DOI: 10.1292/jvms1939.49.841
Aida Y*., Onuma M., Kasai Y., and Izawa H. “Use of viable-cell ELISA for detection of monoclonal antibodies recognizing tumor-associated antigens on bovine lymphosarcoma cells”. Am. J. Vet. Res., 48: 1319-1324, 1987. PMID: 2821851
Aida Y*., Ochiai K., Itoh K., Onuma M., Fujimori F., Fujimoto Y., and Izawa H. “Radiolocalization of bovine lymphosarcoma cells in athymic mice, using a monoclonal antibody against tumor-associated antigens”. Am. J. Vet. Res., 48: 1181-1186, 1987. PMID: 2820277
Aida Y*., Onuma M., Tsukiyama K., Ogawa Y., Fujieda T., Mikami T., and Izawa H. “Monoclonal antibodies define antigenic regions on the major internal protein p24 of bovine leukemia virus (BLV)”. Arch. Virol., 94: 315-321, 1987. PMID: 2437889 DOI: 10.1007/BF01310725
＜1986年＞
１）原著論文
Onuma M., Odawara T., Watarai S., Aida Y., Ochiai K., Syuto B., Matsumoto K., Yasuda T., Fujimoto Y., Izawa H., and Kawakami Y. “Antitumor effect of adriamycin entrapped in liposomes conjugated with monoclonal antibody against tumor- associated antigen of bovine leukemia cells”. Jpn. J. Cancer Res. (Gann), 77: 1161- 1167, 1986. PMID: 3025145
Onuma M., Koyama. H., Aida Y., Okada K., Ogawa Y., Kirisawa R., and Kawakami Y. “Establishment of B-cell lines from tumor of enzootic bovine leucosis”. Leuk. Res., 10: 689-695, 1986. PMID: 3012214 DOI: 10.1016/0145-2126(86)90274-2
Okada M., Ohshima K., Aida Y., and Onuma M. “Immunoelectron microscopy on tumor-associated antigens of bovine leukemia cells”. J. Electron Microscopy, 35: 2325- 2326, 1986.
２）総説
Chermann J. C., and Barre-Sinoussi F.（訳）間陽子、野田亮：AIDS 発症におけるAIDS ウイルスの役割と予防・治療の可能性について AIDS ウイルス最近の知見、細胞工学、第 5 巻、1146-1151 頁、1986
＜1985年＞
１）原著論文
Aida Y., Onuma M., Ogawa Y., Mikami T., and Izawa H. “Tumor-associated antigens on bovine leukemia virus-induced bovine lymphosarcoma identified by monoclonal antibodies”. Cancer Res., 45: 1174-1180, 1985. PMID: 2982484
Aida Y., Onuma M., Mikami T., and Izawa H. “Topographical analysis of tumor- associated antigens on bovine leukemia virus-induced bovine lymphosarcoma”. Cancer Res., 45: 1181-1186, 1985. PMID: 2578875
Onuma M., Aida Y., Okada K., Ohshima K., Kawakami Y., and Izawa H. “Usefulness of monoclonal antibodies for detection of enzootic bovine leukemia cells”. Jpn. J. Cancer Res. (Gann), 76: 959-966, 1985. PMID: 3935626
Onuma M. and Aida Y. “Monoclonal antibodies against tumor-associated antigens of bovine lymphosarcoma: Diagnostic tool for detection of tumor cells”, pp156-159. In the 3rd QQQP Animal Science Congress. Seoul, Korea. 1985.